Ribosome Inactivating Proteins

N-Glycosidases that remove adenines from RIBOSOMAL RNA, depurinating the conserved alpha-sarcin loop of 28S RIBOSOMAL RNA. They often consist of a toxic A subunit and a binding lectin B subunit. They may be considered as PROTEIN SYNTHESIS INHIBITORS. They are found in many PLANTS and have cytotoxic and antiviral activity.

Also Known As:

Polynucleotide Adenosine Glycosidase; RIP (Ribosome Inactivating Proteins); RNA Glycosylase; rRNA N-Glycosylases; Adenosine Glycosidase, Polynucleotide; Glycosidase, Polynucleotide Adenosine; Glycosylase, RNA; Inactivating Proteins, Ribosome; N-Glycosidase, RNA; N-Glycosylases, rRNA; Proteins, Ribosome Inactivating; RNA N Glycosidase; rRNA N Glycosylases; RIP Ribosome Inactivating Proteins; RNA N-Glycosidase

Pharmalogical Action Categories:

Protein Synthesis Inhibitors

Enzymes and Coenzymes: 1
- Enzymes: 155591
  - Hydrolases: 2206
    - Glycoside Hydrolases: 890
      - N-Glycosyl Hydrolases: 37
        Ribosome Inactivating Proteins: 50
Amino Acids, Peptides, and Proteins: 1
- Proteins: 496323
  - Plant Proteins: 352
    - Ribosome Inactivating Proteins: 50

F C Belanger Selected Research

F C Belanger Research Topics

Disease

Drug/Important Bio-Agent (IBA)